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CREB inhibitor
CAS No. 1433286-70-4
CREB inhibitor ( CREB inhibitor )
产品货号. M20071 CAS No. 1433286-70-4
666-15 是一种有效的选择性 CREB 抑制剂 (IC50: 81 nM)。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥915 | 有现货 |
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| 10MG | ￥1442 | 有现货 |
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| 25MG | ￥2940 | 有现货 |
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| 50MG | ￥4682 | 有现货 |
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| 100MG | ￥6747 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称CREB inhibitor
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述666-15 是一种有效的选择性 CREB 抑制剂 (IC50: 81 nM)。
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产品描述666-15 is a potent and selective CREB inhibitor (IC50: 81 nM).
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体外实验Cell Proliferation Assay Cell Line:CTRL or MSN-overexpressing MDA-MB-231 cells Concentration:73 nM Incubation Time:For 12hours Result:Significantly blocked the cell proliferation caused by MSN overexpression.Western Blot Analysis Cell Line:NRCMs Concentration:1 μM Incubation Time:2 hour (pretreated)Result:Effectively inhibited PE-induced CREB phosphorylation.
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体内实验Animal Model:1-month-old female nude mice with MDA-MB-231 or T47D cells Dosage:10 mg/kg Administration:IP; once a week; for 11 weeks Result:Played a good role in inhibiting the growth of breast cancer.
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同义词CREB inhibitor
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通路Chromatin/Epigenetic
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靶点Epigenetic Reader Domain
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受体CREB
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研究领域——
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适应症——
化学信息
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CAS Number1433286-70-4
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分子量620.52
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分子式C33H31Cl2N3O5
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纯度>98% (HPLC)
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溶解度DMSO: 60 mg/mL (96.7 mM)
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SMILESCl.NCCCOc1cc2ccccc2cc1C(=O)NCCOc1cc2ccccc2cc1C(=O)Nc1ccc(Cl)cc1O
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化学全称3-(3-Aminopropoxy)-N-[2-[[3-[[(4-chloro-2-hydroxyphenyl)amino]carbonyl]-2-naphthalenyl]oxy]ethyl]-2-naphthalenecarboxamide hydrochloride
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Xie F et al. Identification of a Potent Inhibitor of CREB-Mediated Gene Transcription with Efficacious in Vivo Anticancer Activity. J Med Chem. 2015 Jun 25;58(12):5075-87.
